The objective of this guideline is to provide harmonised recommendations for the conduct of nonclinical biodistribution (BD) studies in the development of gene therapy (GT) products. Pharmacokinetics Pharmacokinetic parameters are not evaluated in this study. National Library of Medicine The author, Pankaj Prasun, points out that the virus impact on mitochondria helps explain why COVID-19 is so much deadlier for older people, the obese, and those with diabetes, high blood pressure and heart disease. As of August 23, 2021, the Pfizer-BioNTech inoculation is now approved under the brand name Comirnaty. After spending 20 hours of research, I found there are no animal biodistribution studies of mRNA vaccines done by Pfizer, Moderna, or J and J published on an internet search. Over 48 hours, distribution from the injection site to most tissues occurred, with the majority of tissues exhibiting low levels of radioactivity. Would you like email updates of new search results? See the post about the approval for details. Okay I just noticed the link please ignore. In a recent interview1 with Alex Pierson (above), Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., dropped a shocking truth bomb that immediately went viral, despite being censored by Google. After the protein piece is made, the cell breaks down the instructions and gets rid of them. Other research suggests the SARS-CoV-2 spike protein can have a serious impact on your mitochondrial function, which is imperative for good health, innate immunity and disease prevention of all kinds. DO NOT forget Japanese biodistribution study looking at lipid nano-particles in rats & how they bio-accumulated in first 48 hours post administration; understand that this links direct to COVID jabs Dr. Byram Bridle was attacked for his work showing that content of the COVID VACCINE did not stay in the injection site (arm) but leeched into the . 2018;7(1):7886. And, since the spike protein doesnt enter into the membrane of the cell, theres a high risk that it can become problematic if indeed it works like a prion. Spike protein does not attack anything, it only aims to activate the immune response, it is not the same as coronavirus spike protein and after vaccination, it is created in a dose 100 thousand times lower than in viral infection. We now know spike protein gets into circulation. The attack causes damage to the lining, which results in inflammation. Once it gets in the blood, it accumulates in a number of tissues such as the spleen, the bone marrow, the liver, the adrenal glands. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal For Vaxzevria, a single-dose intramuscular biodistribution study with AZD1222 in mice (study 514559) was submitted post-authorisation. The biodistribution was also studied in rats, using radiolabeled LNP and luciferase modRNA (study 185350. The data from this study is not yet available in the public domain but this might provide evidence of vaccine delivery in the brain. New Peer Reviewed Study on COVID-19 Vaccines Suggests Why Heart Inflammation, Blood Clots and Other Dangerous Side Effects Occur. We thought the spike protein was a great target antigen; we never knew the spike protein itself was a toxin and was a pathogenic protein. which is it, did they or did they now know that the spike protein was a toxin/pathogenic for a long time? . No evidence of vaccine-related macroscopic or microscopic findings were found in the ovaries in the repeat-dose toxicity studies (Study 38166 and Study 20GR142), were identified in the DART, Developmental and Reproductive Toxicology, study.*, The bottom line is mRNA Covid vaccines are still considered experimental by the FDA as. what does he mean by long time? Change), You are commenting using your Facebook account. Moreover, ascientific paper just accepted for publicationin the Oxford University Press for the Infectious Diseases Society of America supports this frightening hypothesis. (LogOut/ eCollection 2020 Sep 11. 2021 The Japanese Society for Regenerative Medicine. Assessments of shedding can be utilized . J Altern Complement Med. Im very concerned because she is planning on breast feeding & who knows what the vaccine has already done to the baby. As we reported last June 14, Bridle received a copy of a Japanese biodistribution study, which had been withheld from the public, as a result of a freedom of information request made to the Japanese government for data from Pfizer. 22 23 24 25 Janssen told The BMJ its covid-19 vaccine leverages the same technology as its Ebola vaccine, which received licensure last June. Please enable it to take advantage of the complete set of features! No traditional pharmacokinetic or biodistribution studies have been performed with the vaccine candidate BNT162b2. Shedding is the dissemination of the viral vectors (e.g. I want to pass it on to some doctors in Japan who have no idea about its existence. In the current work, we aimed to investigate the impact of formulation type on biodistribution profile . The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines, The assumption that vaccine developers have been working with is that the mRNA in the vaccines would primarily remain in and around the vaccination site. Accessibility PMC So by vaccinating people, we are inadvertently inoculating them with a toxin.. The Japanese biodistribution study of Pfizer's mRNA vaccine has also found that 0.02% and 0.009% of the vaccine administered dose ended up in the brain at 2-hour and 48-hour, respectively: Unauthorized use of these marks is strictly prohibited. The designers of the COVID-19 vaccines expected the contents of a jab to remain in the muscular tissue where they were injected, usually an arm. This assumption was wrong. A study document obtained from the Japanese regulatory agency shows that the vaccine contents enter the bloodstream and travel to the various organs.Lab animals injected with purified spike protein into their bloodstream developed cardiovascular problems, and the spike protein was also demonstrated to cross the blood brain barrier and cause damage to the brain. In my interview with Seneff and Mikovits (see earlier hyperlink), they both stressed that the key danger both in COVID-19 and with the vaccines is the spike protein itself. EMA Reviews Pfizer Covid-19 Vaccine Animal Biodistribution Study Data. No safety pharmacology studies were conducted with BNT162b2. Most of the studies referenced by EMA are not available on the internet, but can be requested as was done by the Citizens petition. The signal decreased slowly during the first 72 hours and after 6 and 9 days the signals were further weakened to approximately levels of 18 and 7 times the signals obtained from animals injected with buffer control. That same research also establishes that the spike protein alone is almost entirely responsible for damage to the cardiovascular system if circulating in the body. The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. SARS-CoV-2 MRNA Vaccine (BNT162, PF-0 7302048)2.6.4 . Furthermore, in key studies designed to test whether the vaccine remains near the injection site or travels throughout the body, Pfizer did not even use the commercial vaccine (BNT162b2) but instead relied on a surrogate mRNA producing the luciferase protein. official website and that any information you provide is encrypted Brindle, who stated the importance of sharing this new information openly, recently visited On Point with Alex Pierson and spoke at length on the scary situation facing humanity as the push to vaccinate the global population against SARS-CoV-2 gains momentum. Metabolomic studies suggest that SARS-CoV-2 inhibits mitophagy. 2012 Mar;64(3):375-83. doi: 10.1002/acr.21558. The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. Both are important for the clearing of cellular debris, including these spike proteins. So, by vaccinating people we are inadvertently inoculating them with a toxin.. and transmitted securely. High Mutational Heterogeneity, and New Mutations in the Human Coagulation Factor V Gene. https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf. The study is titled, "Placebo-controlled randomized double-blind (evaluators, patients) multi-facility joint parallel-group comparison . To conduct BD studies, it is necessary to understand regulatory requirements, implementation status, and analytical methods. Avoid all vegetable oils and processed foods. Multifunctional NP-based technologies with diagnostic and therapeutic functions are being developed for in vivo applications. Any objections based on the experimental status of this vaccine are now moot. The vaccine-induced spike protein does not do this. The Ministry of Health, Labour and Welfare . Dr Joseph Mercola Story at-a-glance Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. Trends of cell quantification using Alu-qPCR methods. This conclusion was reached by Israeli scientists, who conducted a study that showed that there is no difference in ovarian function between vaccinated and unvaccinated women. 2022 Apr 7;10(4):869. doi: 10.3390/biomedicines10040869. Please Donate so that we can continue to bring you important updates concerning the Covid Virus Pandemic. The Carton Theme by bavotasan.com. Labeled, "Pfizer confidential," the study is known as a bio-distribution study that uses luciferase enzymes and radioisotope markers to accurately track the distribution of Pfizer's mRNA LNPs across the body. This document . Theranostics. A biodistribution study was conducted using ddY mice (male, 5 weeks old). 8.8. From pre-concept to manufacturing startup. Study Design Go to Resource links provided by the National Library of Medicine MedlinePlus Genetics related topics: Alzheimer disease When that happens, it can do one of two things: it can either cause platelets to clump, and that can lead to clottingthats exactly why weve been seeing clotting disorders associated with these vaccines. Bridle details further, explaining: The assumption until now has been that these vaccines behave like all of our traditional vaccines; that they dont go anywhere, they stay in our shoulder. This information is found on the internet leading us to assume, yes, biodistribution studies in animals were conducted by Pfizer. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018 in comparison among (a) local or systemic administration product, (b) commercialized or product in clinical phases, (c) biodistribution measurement modalities, (d) clinical phases of development, (e) used animal species and (f) measurement modalities and biodistribution study duration (refer to Supplementary Table1). Documents obtained from Japanese regulatory agency reveal that Pfizer biodistribution studies showed that mRNA and spike proteins circulate widely throughout the body. When administered, COVID-19 vaccines are injected into the shoulder musclenot into the blood. Nanoparticles with positively charged surfaces tend to accumulate in the liver, lung, and spleen [ 34 ]. Is now approved under the brand name Comirnaty throughout the body the data from study... 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