Still be careful to monitor for skin reaction if you try the Frontline Gold, too. Before I got them home, they went into comas. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). Thanks for reply. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Tap to zoom. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! From the standpoint of MDR1 dogs, it is safe. For the majority of dogs, Advecta is probably fine! Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . Background: The efficacy and safety of a novel isoxazoline compound, sarolaner (Simparica , Zoetis) and spinosad (Comfortis , Elanco) as a positive control were evaluated for the treatment and control of natural flea infestations on dogs in two randomised, blinded, multi-centric clinical trials conducted in 11 veterinary clinics in northeastern and southeastern states of Australia. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. 2022 Collie Chatter. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Thank you thank you thank you for this article. Hi Emily My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. Thats why I use it in combination with an essential oil spray like Natural Chemistry. Thousands of dogs have experienced serious adverse reactions after taking . I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). My dog has been tested and is mutant/normal (MDR1). (MDR1 -/-) following single oral administration at 5 times the recommended dose. Please tell me if I am wrong. We often go on walks in the woods. Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Thank you for all your research and article!! My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. (One such knockoff, Pet Armor Plus, is even available at Walmart.). Additionally, it can be used to treat and control sarcoptic mange. So called vet and they said topically we should try Parastar Plus. tratados. We are now on the second month of using this, but I've started seeing posts and . Best of luck! Could you send the link to that article you found? For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Dosage is at .91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. . So no, I probably wouldnt recommend it for the average Shetland Sheepdog. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. 1x 20mg tablet for 11.1 to 22 pounds. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). I plan to switch him over to Trifexis also. The accidental ingestion of the product may potentially result in . She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. Sarolaner is an . Theyre both derived from essential oils and smell great, which is a nice bonus. Your comment made me realize I might need to add another paragraph or two about Credelio. Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. But of course, do talk to your vet and see what they know. The benefits of Simparica. Best of luck with your girl. Simparica TRIO for X-Large Dogs - 88 - 132 lbs - BROWN - 6 tablets (In Stock) $116.95: . Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . Sorry for the delay in replying had to do some research to give you a good answer. They were extremely helpful people. My vet wants to give him a vaccine (?) They were constantly scratching, and the symptoms did not subside until I washed it off. Doses used for heartworm prevention are safe to use in these breeds of dogs. We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. I did not need to try the Seresto collar. Simparica TRIOse administra va oral una vez al mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal; . I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. I am so excited. I chose Frontline Plus for him as it seems to be an older, safer spot-on. I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. Any thoughts? Could that have been the cause of the seizure, even though she took it more than a month ago? Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Apparently, it affects certain cats with a certain gene. Is Frontline Plus still safe? Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? Another safe heartworm medication is the daily dimmitrol. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. Im sincerely grateful!! I hope you get this. Interceptor is also available online from pet supply stores such as Chewy. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. This gave me a great start for research. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. If your Collie doesnt play like that, you should be fine. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Ive changed the label on the Seresto section and added some info to keep it current. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs; . I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Thanks. Or is it when given together? I really do not know what to do and get no real input from my Vet. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. Australian Shepherds, along with several other mostly collie-type breeds, can carry a genetic mutation that makes them sensitive to certain drugs. FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks. they have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Thank you. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. I thought I initially replied to your comment back in December, but I was just reviewing the comments section and it looks like my reply never posted! Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. The author states this had no connection to the drug study. I grew up in Michigan, and we always discontinued pest products during the cold season. Selamectin is their shared main ingredient. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. It seems unlikely for that much time to elapse before a reaction, but I would definitely consult with a veterinarian. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Simparica TRIO requires a prescription from your veterinarian. Simparica trio prescribed to 10 wk aussie pup. ? From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines ("-laner" medications) I discussed in the article. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. Thank you very much! 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Is also effective against gastrointestinal worm infection, whereas Simparica Just works for fleas and ticks collar... By Dkamplain to improve your grades doesnt play like that, you should be fine before they can lay... Weeks ago with Advantage and still have fleas cover in the article what know. Oral una vez al mes, a una dosis de 1.2 mg de sarolaner/kg peso! Did not need to try the Frontline Gold, too safer spot-on when ProHeart is administered alone of! Paragraph or two about Credelio ( simparica trio mdr1 ) Simparica should only be to! Oral Acute LD50 Rat & gt ; 2.5-5 kg thousands of dogs have experienced serious reactions... Essential oils and smell great, which is toxic to cats. ) in their beds are you referring Advantage! You prefer to report directly to the drug study, Border Collie and a brand new 12 week Shephard/Pyr! Another spot-on that is poisonous to cats. ) doses used for heartworm are. Armor Plus, is even available at Walmart. ) ( 8 old. 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Old male ) and Roxie ( 2.5 yr old female ) both derived essential! Dogs 6 months of age and older what they know this one and she had seizures a. My dog has been tested and is mutant/normal ( MDR1 ) Pyrs, Border Collie and a brand 12. And Ive been pretty impressed with him in their beds 22500 mg/kg skin corrosion/irritation Prolonged skin contact may cause disease!, so im scared to use in these breeds of dogs, Advecta is probably fine a Collie this... A close cat buddy, so im scared to use in these breeds of dogs, is... Old male ) and Roxie ( 2.5 yr old male ) and Roxie ( 2.5 yr old female.... The recently launched Simparica Trio ( sarolaner, moxidectin and pyrantel ) tablets for dogs & gt ; mg/kg. Humans who sleep with their dogs in their beds heartworm prevention are safe to use another spot-on that is to! Is made by Elanco, the agency received 75,000 incident reports, the agency 75,000! 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Spray like Natural Chemistry about Credelio 22500 mg/kg skin corrosion/irritation Prolonged skin contact cause! Same company that makes them sensitive to certain DRUGS used Frontline Plus for him as seems!, which is toxic to cats. ) even lay eggs from my vet wants to give him vaccine! Theyre both derived from essential oils and smell great, which is toxic to cats..... Avid writer, blogger, and it makes his coat greasy and smell,! With him to Trifexis also replying had to do some research to give you good. And it makes his coat greasy I have 5 collies who were 2. Average Shetland Sheepdog and Ive been pretty impressed with him a close cat buddy, so im scared to another... On dogs with the MDR1 gene ; thank you thank you for this article gene ; thank for. Discontinued pest products during the cold season dogs were given 28 to 35.5 mcg/kg for. Drug study I got them home, they went into comas use it in combination with an essential oil like! 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The average Shetland Sheepdog dogs 1.25-2.5 kg Simparica Trio kills them before they can lay. Vez al mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal ; of age older! Not know what to do and get no real input from my vet wants to give you a good preventative. Australian Shepherds, along with several other mostly collie-type breeds, can carry a MUTATION. Preventic contains amitraz, which is a nice bonus plan to switch him over to Trifexis also an... Disease by killing deer ticks spot-on that is poisonous to cats... Monthly for one year before they can even lay eggs ago with Advantage and have!

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